Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

Daniel T. MacLeod, Jeyaraj Antony, Aaron J. Martin, Rachel J. Moser, Armin Hekele, Keith J. Wetzel, Audrey E. Brown, Melissa A. Triggiano, Jo Ann Hux, Christina D. Pham, Victor V. Bartsevich, Caitlin A. Turner, Janel Lape, Samantha Kirkland, Clayton W. Beard, Jeff Smith, Matthew L. Hirsch, Michael G. Nicholson, Derek Jantz, Bruce McCreedy

Mol Ther. 2017 Apr 5; 25(4): 949–961. Published online 2017 Feb 23. doi: 10.1016/j.ymthe.2017.02.005

PMCID: PMC5383629