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Publications

We welcome you to peruse the tables below if you are interested in looking for any publications that Virovek has been involved in.

Peer-Reviewed Articles Published by Virovek
Chen H. Exploiting the intron-splicing mechanism of insect cells to produce viral vectors harboring toxic genes for suicide gene therapy. Mol Ther Nucleic Acids. 2012 Nov 27;1:e57.
Chen H. Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells. Mol Ther. 2008 May;16(5):924-30. Epub 2008 Mar 18.

 

Selected Peer-Reviewed Articles using AAV Vectors Produced by Virovek
Mahiny, AJ; Dewerth, A; Mays, LE; Alkhaled, M; Mothes, B; Malaeksefat, E; Loretz, B; Rottenberger, J; Brosch, DM; Reautschnig, P; Surapolchai, P; Zeyer, F; Schams, A; Carevic, M; Bakele, M; Griese, M; Schwab, M; Nürnberg, B; Beer-Hammer, S; Handgretinger, R; Hartl, D; Lehr, CM; Kormann, MS. In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. Nat. Biotechnol. 2015 Jun 1; 33(6) 584-6. doi: 10.1038/nbt.3241. PMID: 25985262.
Iyer, SM; Montgomery, KL; Towne, C; Lee, SY; Ramakrishnan, C; Deisseroth, K; Delp, SL. Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice. Nat. Biotechnol. 2014 Mar 1; 32(3) 274-8. doi: 10.1038/nbt.2834. PMID: 24531797.
Rezvani, M; Español-Suñer, R; Malato, Y; Dumont, L; Grimm, AA; Kienle, E; Bindman, JG; Wiedtke, E; Hsu, BY; Naqvi, SJ; Schwabe, RF; Corvera, CU; Grimm, D; Willenbring, H. In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis. Cell Stem Cell. 2016 Jun 2; 18(6) 809-16. doi: 10.1016/j.stem.2016.05.005. PMID: 27257763.
Fernandes, MF; Matthys, D; Hryhorczuk, C; Sharma, S; Mogra, S; Alquier, T; Fulton, S. Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons. Cell Metab. 2015 Oct 6; 22(4) 741-9. doi: 10.1016/j.cmet.2015.08.003. PMID: 26341832.
Garfield, AS; Shah, BP; Madara, JC; Burke, LK; Patterson, CM; Flak, J; Neve, RL; Evans, ML; Lowell, BB; Myers, MG; Heisler, LK. A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia. Cell Metab. 2014 Dec 2; 20(6) 1030-7. doi: 10.1016/j.cmet.2014.11.006. PMID: 25470549.
Beas, BS; Wright, BJ; Skirzewski, M; Leng, Y; Hyun, JH; Koita, O; Ringelberg, N; Kwon, HB; Buonanno, A; Penzo, MA. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat. Neurosci. 2018 Jul 1; 21(7) 963-973. doi: 10.1038/s41593-018-0167-4. PMID: 29915192.
Todd, WD; Fenselau, H; Wang, JL; Zhang, R; Machado, NL; Venner, A; Broadhurst, RY; Kaur, S; Lynagh, T; Olson, DP; Lowell, BB; Fuller, PM; Saper, CB. A hypothalamic circuit for the circadian control of aggression. Nat. Neurosci. 2018 May 1; 21(5) 717-724. doi: 10.1038/s41593-018-0126-0. PMID: 29632359.
Fenselau, H; Campbell, JN; Verstegen, AM; Madara, JC; Xu, J; Shah, BP; Resch, JM; Yang, Z; Mandelblat-Cerf, Y; Livneh, Y; Lowell, BB. A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH. Nat. Neurosci. 2017 Jan 1; 20(1) 42-51. doi: 10.1038/nn.4442. PMID: 27869800.
Garfield, AS; Li, C; Madara, JC; Shah, BP; Webber, E; Steger, JS; Campbell, JN; Gavrilova, O; Lee, CE; Olson, DP; Elmquist, JK; Tannous, BA; Krashes, MJ; Lowell, BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nat. Neurosci. 2015 Jun 1; 18(6) 863-71. doi: 10.1038/nn.4011. PMID: 25915476.
Sanchez-Padilla, J; Guzman, JN; Ilijic, E; Kondapalli, J; Galtieri, DJ; Yang, B; Schieber, S; Oertel, W; Wokosin, D; Schumacker, PT; Surmeier, DJ. Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat. Neurosci. 2014 Jun 1; 17(6) 832-40. doi: 10.1038/nn.3717. PMID: 24816140.
Cole, CJ; Mercaldo, V; Restivo, L; Yiu, AP; Sekeres, MJ; Han, JH; Vetere, G; Pekar, T; Ross, PJ; Neve, RL; Frankland, PW; Josselyn, SA. MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nat. Neurosci. 2012 Sep 1; 15(9) 1255-64. doi: 10.1038/nn.3189. PMID: 22885849.
Resch, JM; Fenselau, H; Madara, JC; Wu, C; Campbell, JN; Lyubetskaya, A; Dawes, BA; Tsai, LT; Li, MM; Livneh, Y; Ke, Q; Kang, PM; Fejes-Tóth, G; Náray-Fejes-Tóth, A; Geerling, JC; Lowell, BB. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017 Sep 27; 96(1) 190-206.e7. doi: 10.1016/j.neuron.2017.09.014. PMID: 28957668.
Boehringer, R; Polygalov, D; Huang, AJY; Middleton, SJ; Robert, V; Wintzer, ME; Piskorowski, RA; Chevaleyre, V; McHugh, TJ. Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability. Neuron. 2017 May 3; 94(3) 642-655.e9. doi: 10.1016/j.neuron.2017.04.014. PMID: 28472661.
Plotkin, JL; Day, M; Peterson, JD; Xie, Z; Kress, GJ; Rafalovich, I; Kondapalli, J; Gertler, TS; Flajolet, M; Greengard, P; Stavarache, M; Kaplitt, MG; Rosinski, J; Chan, CS; Surmeier, DJ. Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease. Neuron. 2014 Jul 2; 83(1) 178-88. doi: 10.1016/j.neuron.2014.05.032. PMID: 24991961.
Yao, XQ; Jiao, SS; Saadipour, K; Zeng, F; Wang, QH; Zhu, C; Shen, LL; Zeng, GH; Liang, CR; Wang, J; Liu, YH; Hou, HY; Xu, X; Su, YP; Fan, XT; Xiao, HL; Lue, LF; Zeng, YQ; Giunta, B; Zhong, JH; Walker, DG; Zhou, HD; Tan, J; Zhou, XF; Wang, YJ. p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease. Mol. Psychiatry. 2015 Nov 1; 20(11) 1301-10. doi: 10.1038/mp.2015.49. PMID: 25917367.
Meyer, RM; Burgos-Robles, A; Liu, E; Correia, SS; Goosens, KA. A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol. Psychiatry. 2014 Dec 1; 19(12) 1284-94. doi: 10.1038/mp.2013.135. PMID: 24126924.
Guzman, JN; Ilijic, E; Yang, B; Sanchez-Padilla, J; Wokosin, D; Galtieri, D; Kondapalli, J; Schumacker, PT; Surmeier, DJ. Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress. J. Clin. Invest. 2018 Jun 1; 128(6) 2266-2280. doi: 10.1172/JCI95898. PMID: 29708514.
Shi, Z; Madden, CJ; Brooks, VL. Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways. J. Clin. Invest. 2017 Jun 30; 127(7) 2868-2880. doi: 10.1172/JCI92008. PMID: 28628036.
Ruegsegger, C; Maharjan, N; Goswami, A; Filézac de L'Etang, A; Weis, J; Troost, D; Heller, M; Gut, H; Saxena, S. Aberrant association of misfolded SOD1 with Na(+)/K(+)ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS. Acta Neuropathol. 2016 Mar 1; 131(3) 427-51. doi: 10.1007/s00401-015-1510-4. PMID: 26619836.
Ward, ME; Taubes, A; Chen, R; Miller, BL; Sephton, CF; Gelfand, JM; Minami, S; Boscardin, J; Martens, LH; Seeley, WW; Yu, G; Herz, J; Filiano, AJ; Arrant, AE; Roberson, ED; Kraft, TW; Farese, RV; Green, A; Gan, L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J. Exp. Med. 2014 Sep 22; 211(10) 1937-45. doi: 10.1084/jem.20140214. PMID: 25155018.
Li, Y; Andereggen, L; Yuki, K; Omura, K; Yin, Y; Gilbert, HY; Erdogan, B; Asdourian, MS; Shrock, C; de Lima, S; Apfel, UP; Zhuo, Y; Hershfinkel, M; Lippard, SJ; Rosenberg, PA; Benowitz, L. Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Proc. Natl. Acad. Sci. U.S.A. 2017 Jan 10; 114(2) E209-E218. doi: 10.1073/pnas.1616811114. PMID: 28049831.
Parikh, P; Hao, Y; Hosseinkhani, M; Patil, SB; Huntley, GW; Tessier-Lavigne, M; Zou, H. Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons. Proc. Natl. Acad. Sci. U.S.A. 2011 May 10; 108(19) E99-107. doi: 10.1073/pnas.1100426108. PMID: 21518886.
Liu, CH; Coleman, JE; Davoudi, H; Zhang, K; Hussain Shuler, MG. Selective activation of a putative reinforcement signal conditions cued interval timing in primary visual cortex. Curr. Biol. 2015 Jun 15; 25(12) 1551-61. doi: 10.1016/j.cub.2015.04.028. PMID: 26004763.
Cho, SK; Kwon, YJ. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials. 2012 Apr 1; 33(11) 3316-23. doi: 10.1016/j.biomaterials.2012.01.027. PMID: 22281425.
Kuo, CY; Long, JD; Campo-Fernandez, B; de Oliveira, S; Cooper, AR; Romero, Z; Hoban, MD; Joglekar, AV; Lill, GR; Kaufman, ML; Fitz-Gibbon, S; Wang, X; Hollis, RP; Kohn, DB. Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome. Cell Rep. 2018 May 29; 23(9) 2606-2616. doi: 10.1016/j.celrep.2018.04.103. PMID: 29847792.
Hachigian, LJ; Carmona, V; Fenster, RJ; Kulicke, R; Heilbut, A; Sittler, A; Pereira de Almeida, L; Mesirov, JP; Gao, F; Kolaczyk, ED; Heiman, M. Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2. Cell Rep. 2017 Dec 5; 21(10) 2688-2695. doi: 10.1016/j.celrep.2017.11.018. PMID: 29212017.
Gantz, SC; Levitt, ES; Llamosas, N; Neve, KA; Williams, JT. Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA. Cell Rep. 2015 Aug 11; 12(6) 944-54. doi: 10.1016/j.celrep.2015.07.005. PMID: 26235617.
Lo, B; Strasser, G; Sagolla, M; Austin, CD; Junttila, M; Mellman, I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J. Cell Biol. 2012 Dec 24; 199(7) 1117-30. doi: 10.1083/jcb.201208080. PMID: 23266956.
Ross, RA; Leon, S; Madara, JC; Schafer, D; Fergani, C; Maguire, CA; Verstegen, AM; Brengle, E; Kong, D; Herbison, AE; Kaiser, UB; Lowell, BB; Navarro, VM. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 Jun 15; 7. doi: 10.7554/eLife.35960. PMID: 29905528.
Arttamangkul, S; Heinz, DA; Bunzow, JR; Song, X; Williams, JT. Cellular tolerance at the µ-opioid receptor is phosphorylation dependent. Elife. 2018 Mar 28; 7. doi: 10.7554/eLife.34989. PMID: 29589831.
Burkett, ZD; Day, NF; Kimball, TH; Aamodt, CM; Heston, JB; Hilliard, AT; Xiao, X; White, SA. FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch. Elife. 2018 Jan 23; 7. doi: 10.7554/eLife.30649. PMID: 29360038.
Fremont, R; Tewari, A; Angueyra, C; Khodakhah, K. A role for cerebellum in the hereditary dystonia DYT1. Elife. 2017 Feb 15; 6. doi: 10.7554/eLife.22775. PMID: 28198698.
Yu, XW; Curlik, DM; Oh, MM; Yin, JC; Disterhoft, JF. CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats. Elife. 2017 Jan 4; 6. doi: 10.7554/eLife.19358. PMID: 28051768.
Sørensen, AT; Cooper, YA; Baratta, MV; Weng, FJ; Zhang, Y; Ramamoorthi, K; Fropf, R; LaVerriere, E; Xue, J; Young, A; Schneider, C; Gøtzsche, CR; Hemberg, M; Yin, JC; Maier, SF; Lin, Y. A robust activity marking system for exploring active neuronal ensembles. Elife. 2016 Sep 23; 5. doi: 10.7554/eLife.13918. PMID: 27661450.
Gantz, SC; Robinson, BG; Buck, DC; Bunzow, JR; Neve, RL; Williams, JT; Neve, KA. Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium. Elife. 2015 Aug 26; 4. doi: 10.7554/eLife.09358. PMID: 26308580.
Westmeyer, GG; Emer, Y; Lintelmann, J; Jasanoff, A. MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch. Chem. Biol. 2014 Mar 20; 21(3) 422-9. doi: 10.1016/j.chembiol.2014.01.012. PMID: 24613020.
MacLeod, DT; Antony, J; Martin, AJ; Moser, RJ; Hekele, A; Wetzel, KJ; Brown, AE; Triggiano, MA; Hux, JA; Pham, CD; Bartsevich, VV; Turner, CA; Lape, J; Kirkland, S; Beard, CW; Smith, J; Hirsch, ML; Nicholson, MG; Jantz, D; McCreedy, B. Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells. Mol. Ther. 2017 Apr 5; 25(4) 949-961. doi: 10.1016/j.ymthe.2017.02.005. PMID: 28237835.
Suhy, DA; Kao, SC; Mao, T; Whiteley, L; Denise, H; Souberbielle, B; Burdick, AD; Hayes, K; Wright, JF; Lavender, H; Roelvink, P; Kolykhalov, A; Brady, K; Moschos, SA; Hauck, B; Zelenaia, O; Zhou, S; Scribner, C; High, KA; Renison, SH; Corbau, R. Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model. Mol. Ther. 2012 Sep 1; 20(9) 1737-49. doi: 10.1038/mt.2012.119. PMID: 22735378.
Serotype, RAAV. Scalable Process for Puri cation of Recombinant Adeno-Associated Virus Serotype 9. Molecular Therapy. 2010 Jan 0.
Bai, YY; Ruan, CS; Yang, CR; Li, JY; Kang, ZL; Zhou, L; Liu, D; Zeng, YQ; Wang, TH; Tian, CF; Liao, H; Bobrovskaya, L; Zhou, XF. ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress. Neuropsychopharmacology. 2016 Nov 1; 41(12) 2882-2892. doi: 10.1038/npp.2016.100. PMID: 27312407.
Lewis, CR; Bastle, RM; Manning, TB; Himes, SM; Fennig, P; Conrad, PR; Colwell, J; Pagni, BA; Hess, LA; Matekel, CG; Newbern, JM; Olive, MF. Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats. Neuropsychopharmacology. 2016 Nov 1; 41(12) 2851-2861. doi: 10.1038/npp.2016.96. PMID: 27312406.
Soumier, A; Sibille, E. Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice. Neuropsychopharmacology. 2014 Aug 1; 39(9) 2252-62. doi: 10.1038/npp.2014.76. PMID: 24690741.
Nischal, H; Sun, H; Wang, Y; Ford, DA; Cao, Y; Wei, P; Teng, BB. Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice. Mol Ther Nucleic Acids. 2013 Oct 1; 2. e125. doi: 10.1038/mtna.2013.53. PMID: 24084845.
Laperrousaz, E; Moullé, VS; Denis, RG; Kassis, N; Berland, C; Colsch, B; Fioramonti, X; Philippe, E; Lacombe, A; Vanacker, C; Butin, N; Bruce, KD; Wang, H; Wang, Y; Gao, Y; Garcia-Caceres, C; Prévot, V; Tschöp, MH; Eckel, RH; Le Stunff, H; Luquet, S; Magnan, C; Cruciani-Guglielmacci, C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia. 2017 Jul 1; 60(7) 1314-1324. doi: 10.1007/s00125-017-4282-7. PMID: 28456865.
David, F; Çarçak, N; Furdan, S; Onat, F; Gould, T; Mészáros, Á; Di Giovanni, G; Hernández, VM; Chan, CS; Lőrincz, ML; Crunelli, V. Suppression of HCN channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. J. Neurosci. 2018 Jun 20. doi: 10.1523/JNEUROSCI.0896-17.2018. PMID: 29925625.
Heston, JB; White, SA. Behavior-linked FoxP2 regulation enables zebra finch vocal learning. J. Neurosci. 2015 Feb 18; 35(7) 2885-94. doi: 10.1523/JNEUROSCI.3715-14.2015. PMID: 25698728.
Chávez, AE; Hernández, VM; Rodenas-Ruano, A; Chan, CS; Castillo, PE. Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus. J. Neurosci. 2014 Dec 10; 34(50) 16621-9. doi: 10.1523/JNEUROSCI.3635-14.2014. PMID: 25505315.
Cook-Snyder, DR; Jones, A; Reijmers, LG. A retrograde adeno-associated virus for collecting ribosome-bound mRNA from anatomically defined projection neurons. Front Mol Neurosci. 2015 Sep 24; 8. 56. doi: 10.3389/fnmol.2015.00056. PMID: 26557053.
Fremont, R; Tewari, A; Khodakhah, K. Aberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia-Parkinsonism. Neurobiol. Dis. 2015 Oct 1; 82. 200-212. doi: 10.1016/j.nbd.2015.06.004. PMID: 26093171.
Jiao, SS; Shen, LL; Zhu, C; Bu, XL; Liu, YH; Liu, CH; Yao, XQ; Zhang, LL; Zhou, HD; Walker, DG; Tan, J; Götz, J; Zhou, XF; Wang, YJ. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Transl Psychiatry. 2016 Oct 4; 6(10) e907. doi: 10.1038/tp.2016.186. PMID: 27701410.
Ivanova, E; Yee, CW; Sagdullaev, BT. Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina. Front Cell Neurosci. 2015 Oct 1; 9. 390. doi: 10.3389/fncel.2015.00390. PMID: 26483638.
Luo, C; Zhong, XL; Zhou, FH; Li, JY; Zhou, P; Xu, JM; Song, B; Li, CQ; Zhou, XF; Dai, RP. Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator. Sci Rep. 2016 Jun 2; 6. 27171. doi: 10.1038/srep27171. PMID: 27251195.
Jin, SX; Arai, J; Tian, X; Kumar-Singh, R; Feig, LA. Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP). J. Biol. Chem. 2013 Jul 26; 288(30) 21703-13. doi: 10.1074/jbc.M113.471904. PMID: 23766509.
Wang, QH; Wang, YR; Zhang, T; Jiao, SS; Liu, YH; Zeng, F; Li, J; Yao, XQ; Zhou, HD; Zhou, XF; Wang, YJ. Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice. J. Neurochem. 2016 Jul 1; 138(1) 163-73. doi: 10.1111/jnc.13616. PMID: 26991827.
Saadipour, K; Yang, M; Lim, Y; Georgiou, K; Sun, Y; Keating, D; Liu, J; Wang, YR; Gai, WP; Zhong, JH; Wang, YJ; Zhou, XF. Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway. J. Neurochem. 2013 Oct 1; 127(2) 152-62. doi: 10.1111/jnc.12383. PMID: 23895422.
Chen, J; Zhang, T; Jiao, S; Zhou, X; Zhong, J; Wang, Y; Liu, J; Deng, J; Wang, S; Xu, Z. proBDNF Accelerates Brain Amyloid-β Deposition and Learning and Memory Impairment in APPswePS1dE9 Transgenic Mice. J. Alzheimers Dis. 2017 Jul 13; 59(3) 941-949. doi: 10.3233/JAD-161191. PMID: 28697556.
Sato, M; Kawano, M; Yanagawa, Y; Hayashi, Y. In vivo two-photon imaging of striatal neuronal circuits in mice. Neurobiol Learn Mem. 2016 Nov 1; 135. 146-151. doi: 10.1016/j.nlm.2016.07.006. PMID: 27400866.
Maimon, B; Zorzos, A; Bendell, R; Harding, A; Fahmi, M; Srinivasan, S; Calvaresi, P; Herr, H. Transdermal optogenetic peripheral nerve stimulation. J. Neural Eng. 2017 Jun 1; 14(3) 034002. doi: 10.1088/1741-2552/aa5e20.
Lavinsky, D; Chalberg, TW; Mandel, Y; Huie, P; Dalal, R; Marmor, M; Palanker, D. Modulation of transgene expression in retinal gene therapy by selective laser treatment. Invest. Ophthalmol. Vis. Sci. 2013 Mar 13; 54(3) 1873-80. doi: 10.1167/iovs.12-10933. PMID: 23422827.
Neve, KA; Ford, CP; Buck, DC; Grandy, DK; Neve, RL; Phillips, TJ. Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S. Neuroscience. 2013 Sep 17; 248. 479-87. doi: 10.1016/j.neuroscience.2013.06.035. PMID: 23811070.
Ivanova, E; Yee, CW; Sagdullaev, BT. Disruption in dopaminergic innervation during photoreceptor degeneration. J. Comp. Neurol. 2016 Apr 15; 524(6) 1208-21. doi: 10.1002/cne.23899. PMID: 26356010.
Lu, Q; Ganjawala, TH; Ivanova, E; Cheng, JG; Troilo, D; Pan, ZH. AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates. Gene Ther. 2016 Aug 1; 23(8-9) 680-9. doi: 10.1038/gt.2016.42. PMID: 27115727.
Greenberg, B; Butler, J; Felker, GM; Ponikowski, P; Voors, AA; Pogoda, JM; Provost, R; Guerrero, J; Hajjar, RJ; Zsebo, KM. Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure. Gene Ther. 2016 Mar 1; 23(3) 313-9. doi: 10.1038/gt.2015.109. PMID: 26699914.
Neuner, SM; Wilmott, LA; Hope, KA; Hoffmann, B; Chong, JA; Abramowitz, J; Birnbaumer, L; O'Connell, KM; Tryba, AK; Greene, AS; Savio Chan, C; Kaczorowski, CC. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav. Brain Res. 2015 Mar 15; 281. 69-77. doi: 10.1016/j.bbr.2014.12.018. PMID: 25513972.
Peng, C; Yan, Y; Kim, VJ; Engle, SE; Berry, JN; McIntosh, JM; Neve, RL; Drenan, RM. Gene Editing Vectors for Studying Nicotinic Acetylcholine Receptors in Cholinergic Transmission. Eur. J. Neurosci. 2018 May 19. doi: 10.1111/ejn.13957. PMID: 29779223.
Hammond, SL; Leek, AN; Richman, EH; Tjalkens, RB. Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. PLoS ONE. 2017 Dec 15; 12(12) e0188830. doi: 10.1371/journal.pone.0188830. PMID: 29244806.
Barajas, D; Aponte-Ubillus, JJ; Akeefe, H; Cinek, T; Peltier, J; Gold, D. Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae. PLoS ONE. 2017 Mar 29; 12(3) e0173010. doi: 10.1371/journal.pone.0173010. PMID: 28355224.
Estep, CM; Galtieri, DJ; Zampese, E; Goldberg, JA; Brichta, L; Greengard, P; Surmeier, DJ. Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons. PLoS ONE. 2016 Dec 30; 11(12) e0169044. doi: 10.1371/journal.pone.0169044. PMID: 28036359.
Moreno, CL; Yang, L; Dacks, PA; Isoda, F; Deursen, JM; Mobbs, CV. Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates. PLoS ONE. 2016 Nov 10; 11(11) e0166381. doi: 10.1371/journal.pone.0166381. PMID: 27832201.
Ahn, M; Bajsarowicz, K; Oehler, A; Lemus, A; Bankiewicz, K; DeArmond, SJ. Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice. PLoS ONE. 2014 May 27; 9(5) e98496. doi: 10.1371/journal.pone.0098496. PMID: 24866748.
Dover, N; Barash, JR; Burke, JN; Hill, KK; Detter, JC; Arnon, SS. Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters. PLoS ONE. 2014 May 22; 9(5) e97983. doi: 10.1371/journal.pone.0097983. PMID: 24853378.
Dong, B; Duan, X; Chow, HY; Chen, L; Lu, H; Wu, W; Hauck, B; Wright, F; Kapranov, P; Xiao, W. Proteomics analysis of co-purifying cellular proteins associated with rAAV vectors. PLoS ONE. 2014 Feb 3; 9(2) e86453. doi: 10.1371/journal.pone.0086453. PMID: 24498275.
Wang, W; Nan, Y; Pan, ZH; Pu, M. Morphological evaluation of retinal ganglion cells expressing the L132C/T159C ChR2 mutant transgene in young adult cynomolgus monkeys. Sci China Life Sci. 2017 Nov 1; 60(11) 1157-1167. doi: 10.1007/s11427-017-9055-x. PMID: 28550523.
Heston, JB; White, SA. To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 2017 Sep 1; 203(9) 691-706. doi: 10.1007/s00359-017-1153-0. PMID: 28271185.
Hass, CA; Glickfeld, LL. High-fidelity optical excitation of cortico-cortical projections at physiological frequencies. J. Neurophysiol. 2016 Nov 1; 116(5) 2056-2066. doi: 10.1152/jn.00456.2016. PMID: 27489370.
Cao, W; Chang, YF; Zhao, AC; Chen, BD; Liu, F; Ma, YT; Ma, X. Synergistic cardioprotective effects of rAAV9-CyclinA2 combined with fibrin glue in rats after myocardial infarction. J. Mol. Histol. 2017 Aug 1; 48(4) 275-283. doi: 10.1007/s10735-017-9725-4. PMID: 28643114.
McLean, JR; Smith, GA; Rocha, EM; Hayes, MA; Beagan, JA; Hallett, PJ; Isacson, O. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neurosci. Lett. 2014 Jul 25; 576. 73-8. doi: 10.1016/j.neulet.2014.05.044. PMID: 24882721.
Tao, J; Abudoukelimu, M; Ma, YT; Yang, YN; Li, XM; Chen, BD; Liu, F; He, CH; Li, HY. Secreted frizzled related protein 1 protects H9C2 cells from hypoxia/re-oxygenation injury by blocking the Wnt signaling pathway. Lipids Health Dis. 2016 Apr 6; 15. 72. doi: 10.1186/s12944-016-0240-5. PMID: 27048460.
Tao, J; Chen, BD; Ma, YT; Yang, YN; Li, XM; Ma, X; Yu, ZX; Liu, F; Xiang, Y; Chen, Y. FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway. Lipids Health Dis. 2015 Aug 18; 14. 90. doi: 10.1186/s12944-015-0088-0. PMID: 26282432.
Sun, Z; Ma, YT; Chen, BD; Liu, F. Recombinant adeno-associated virus serotype 9 with p65 ribozyme protects H9c2 cells from oxidative stress through inhibiting NF-κB signaling pathway. J Geriatr Cardiol. 2014 Dec 1; 11(4) 311-5. doi: 10.11909/j.issn.1671-5411.2014.04.006.
Choi, S; Park, H; Minelko, M; Kim, EK; Cho, MR; Nam, JH. Recombinant Adeno-Associated Virus Expressing Truncated IK Cytokine Diminishes the Symptoms of Inflammatory Arthritis. J. Microbiol. Biotechnol. 2017 Oct 28; 27(10) 1892-1895. doi: 10.4014/jmb.1705.05018. PMID: 28683532.
Zhang, HS; Kim, E; Lee, S; Ahn, IS; Jang, JH. Transduction of striatum and cortex tissues by adeno-associated viral vectors produced by herpes simplex virus- and baculovirus-based methods. J. Virol. Methods. 2012 Jan 1; 179(1) 276-80. doi: 10.10.004. PMID: 22015677.
Chen, Q; Zhai, H; Li, X; Ma, Y; Chen, B; Liu, F; Lai, H; Xie, J; He, C; Luo, J; Gao, J; Yang, Y. Recombinant adeno-associated virus serotype 9 in a mouse model of atherosclerosis: Determination of the optimal expression time in vivo. Mol Med Rep. 2017 Apr 1; 15(4) 2090-2096. doi: 10.3892/mmr.2017.6235. PMID: 28260093.
Ma, X; Zhao, A; Yao, Y; Cao, W; Karmacharya, U; Liu, F; Chen, B; Baozhu, W; Ying, H; Ma, Y. Therapeutic delivery of cyclin-A2 via recombinant adeno-associated virus serotype 9 restarts the myocardial cell cycle: an in vitro study. Mol Med Rep. 2015 May 1; 11(5) 3652-8. doi: 10.3892/mmr.2015.3147. PMID: 25571913.
Yang, YN; Ji, WN; Ma, YT; Li, XM; Chen, BD; Xiang, Y; Liu, F. Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes. Genet. Mol. Res. 2012 Dec 21; 11(4) 4672-81. doi: 10.4238/2012.October.17.1. PMID: 23096919.
Chen, BD; He, CH; Chen, XC; Pan, S; Liu, F; Ma, X; Li, XM; Gai, MT; Tao, J; Ma, YT; Yang, YN; Gao, XM. Targeting transgene to the heart and liver with AAV9 by different promoters. Clin. Exp. Pharmacol. Physiol. 2015 Oct 1; 42(10) 1108-17. doi: 10.1111/1440-1681.12453. PMID: 26173818.
Heston, JB; Simon, J; Day, NF; Coleman, MJ; White, SA. Bidirectional scaling of vocal variability by an avian cortico-basal ganglia circuit. Physiol Rep. 2018 Apr 1; 6(8) e13638. doi: 10.14814/phy2.13638. PMID: 29687960.
Dolzani, SD; Baratta, MV; Moss, JM; Leslie, NL; Tilden, SG; Sørensen, AT; Watkins, LR; Lin, Y; Maier, SF. Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females. eNeuro. 2018 Mar 6; 5(1). doi: 10.1523/ENEURO.0025-18.2018. PMID: 29516036.
Lieberman, OJ; Choi, SJ; Kanter, E; Saverchenko, A; Frier, MD; Fiore, GM; Wu, M; Kondapalli, J; Zampese, E; Surmeier, DJ; Sulzer, D; Mosharov, EV. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. 2017 Nov 21; 4(6). doi: 10.1523/ENEURO.0167-17.2017. PMID: 29177188.
Song, G; Poon, CS. α2-Adrenergic blockade rescues hypoglossal motor defense against obstructive sleep apnea. JCI Insight. 2017 Feb 23; 2(4) e91456. doi: 10.1172/jci.insight.91456. PMID: 28239660.
Amaro, IA; Henderson, LA. An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model. J Neurodegener Dis. 2016 Aug 10; 2016. 7120753. doi: 10.1155/2016/7120753. PMID: 27595037.
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Ma X, Yao YZ, Chen BD, Ji WN, Ma YT. Feasibility and safety of adeno-associated virus serotype 9 transfection of neonatal rat cardiomyocytes. Chinese J Tissue Engineering Res. 2012 Jan 8; 10(2):277-81. Available online PDF (Chinese)
Pan ZH, Ganjawala TH, Lu Q, Ivanova E, Zhang Z. ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration. PLoS One. 2014 Jun 5; 9(6):e98924. doi: 10.1371/journal.pone.0098924. eCollection 2014. PMID: 24901492; PDF

 

Selected Peer-Reviewed Articles Citing Virovek's Published Work
Gray JT, Zolotukhin S. Design and construction of functional AAV vectors. Methods Mol Biol. 2011;807:25-46. PMID: 22034025 PMID: 22034025; PDF
Galibert L, Merten OW. Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases. J Invertebr Pathol. 2011 Jul;107 Suppl:S80-93. PMID: 21784234
Lu H, Qu G, Yang X, Xu R, Xiao W. Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver. Hum Gene Ther. 2011 May;22(5):625-32. PMID: 21244243; PDF
Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther. 2009 Nov;17(11):1888-96. PMID: 19532142; PDF
Aslandi G. Lamb K, Zolotukhin S. An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells. Proc Natl Acad Sci USA. 2009 Mar 31;106(13):5059-64. PMID: 19279219; PDF
Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clin Vaccine Immunol. 2009 May;16(5):597-604. PMID: 19244471; PDF
Youjin S, Jun Y. The treatment of hemophilia A: from protein replacement to AAV-mediated gene therapy. Biotechnol Lett. 2009 Mar;31(3):321-8. PMID: 18979215; PDF

 

Book Chapters Citing Virovek's Published Work
Grieger JC, Samulski RJ. Adeno-associated virus vectorology, manufacturing, and clinical applications. Methods Enzymol. 2012;507:229-54. Copyright © 2012 Elsevier Inc. All rights reserved. PMID: 22365777
Snyder RO, Moullier P. Adeno-Associated Virus: Methods and Protocols (Methods in Molecular Biology) [Hardcover]. Publication Date: October 28, 2011. ISBN-10: 1617793698. ISBN-13: 978-1617796391. Edition: 2011. Springer Protocols publication
Merten OW, Al-Rubeai M. Viral Vectors for Gene Therapy : Methods and Protocols [Hardcover]. Publication Date: May 19, 2011. ISBN-10: 161779094X. ISBN-13: 978-1617790942. Edition: 2011. Springer Protocols publication