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  • Publications


    Selected Peer-Reviewed Articles Using AAV Vectors Produced by Virovek

    Pan ZH, Ganjawala TH, Lu Q, Ivanova E, Zhang Z. ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration. PLoS One. 2014 Jun 5;9(6):e98924. doi: 10.1371/journal.pone.0098924. eCollection 2014. PMID: 24901492PDF

    Iyer SM, Montgomery KL, Towne C, Lee SY, Ramakrishnan C, Deisseroth K, Delp SL. Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice. Nat Biotechnol. 2014 Mar;32(3):274-8. doi: 10.1038/nbt.2834. Epub 2014 Feb 16. PMID: 24531797

    Ahn M, Bajsarowicz K, Oehler A, Lemus A, Bankiewicz K, DeArmond SJ. Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice.  PLoS One. 2014 May 27;9(5):e98496. doi: 10.1371/journal.pone.0098496. eCollection 2014. PMID: 24866748PDF

    Westmeyer GG, Emer Y, Lintelmann J, Jasanoff A. MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch. Chem Biol. 2014 Mar 20;21(3):422-9. doi: 10.1016/j.chembiol.2014.01.012. Epub 2014 Mar 6. PMID: 24613020PDF

    Dong B, Duan X, Chow HY, Chen L, Lu H, Wu W, Hauck B, Wright F, Kapranov P, Xiao W. Proteomics analysis of co-purifying cellular proteins associated with rAAV vectors. PLoS One. 2014 Feb 3;9(2):e86453. doi: 10.1371/journal.pone.0086453. eCollection 2014. PMID: 24498275PDF

    Meyer RM, Burgos-Robles A, Liu E, Correia SS, Goosens KA. A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol Psychiatry. 2013 Oct 15. doi: 10.1038/mp.2013.135. [Epub ahead of print]. PMID: 24126924PDF

    Nischal H, Sun H, Wang Y, Ford DA, Cao Y, Wei P, Teng BB. Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice. Mol Ther Nucleic Acids. 2013 Oct 1;2:e125. doi: 10.1038/mtna.2013.53. PMID: 24084845PDF

    Saadipour K, Yang M, Lim Y, Georgiou K, Sun Y, Keating D, Liu J, Wang YR, Gai WP, Zhong JH, Wang YJ, Zhou XF. Amyloid beta1-42 (Aβ42 ) up-regulates the expression of sortilin via the p75NTR /RhoA signaling pathway. J Neurochem. 2013 Oct;127(2):152-62. doi: 10.1111/jnc.12383. Epub 2013 Aug 22. PMID: 23895422

    Neve KA, Ford CP, Buck DC, Grandy DK, Neve RL, Phillips TJ. Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: Comparing D2L and D2S. Neuroscience. 2013 Jun 27;248C:479-487. doi: 10.1016/j.neuroscience.2013.06.035. [Epub ahead of print]. PMID: 23811070PDF

    Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA. Acquisition of Contextual Discrimination Involves the Appearance of a Ras-GRF1/p38 Map Kinase-Mediated Signaling Pathway that Promotes LTP. J Biol Chem. 2013 July 26;288(30):21703-13. PMID: 23766509

    Lavinsky D, Chalberg TW, Mandel Y, Huie P, Dalal R, Marmor M, Palanker D. Modulation of transgene expression in retinal gene therapy by selective laser treatment. Invest Ophthalmol Vis Sci. 2013 Mar 13;54(3):1873-80. PMID: 23422827PDF

    Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol. 2012 Dec 24;199(7):1117-30. PMID: 23266956PDF

    Yang YN, Ji WN, Ma YT, Li XM, Chen BD, Xiang Y, Liu F. Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes. Genet Mol Res. 2012 Dec 21;11(4):4672-81. PMID: 23096919PDF

    Cole CJ, Mercaldo V, Restivo L, Yiu AP, Sekeres MJ, Han JH, Vetere G, Pekar T, Ross PJ, Neve RL, Frankland PW, Josselyn SA. MEF2 negatively regulates learning-induced structural plasticity and memory formation. Nat Neurosci. 2012 Sep;15(9):1255-64. PMID: 22885849

    Suhy DA, Kao SC, Mao T, Whiteley L, Denise H, Souberbielle B, Burdick AD, Hayes K, Wright JF, Lavender H, Roelvink P, Kolykhalov A, Brady K, Moschos SA, Hauck B, Zelenaia O, Zhou S, Scribner C, High KA, Renison SH, Corbau R. Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model. Mol Ther. 2012 Sep;20(9):1737-49. PMID: 22735378PDF

    Cho SK, Kwon YJ. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials. 2012 Apr;33(11):3316-23. PMID: 22281425PDF

    Ma X, Yao YZ, Chen BD, Ji WN, Ma YT. Feasibility and safety of adeno-associated virus serotype 9 transfection of neonatal rat cardiomyocytes. Chinese J Tissue Engineering Res. 2012 Jan 8;10(2):277-81. Available online PDF (Chinese)

    Zhang HS, Kim E, Lee S, Ahn IS, Jang JH. Transduction of striatum and cortex tissues by adeno-associated viral vectors produced by herpes simplex virus- and baculovirus-based methods. J Virol Methods. 2012 Jan;179(1):276-80. PMID: 22015677PDF

    Parikh P, Hao Y, Hosseinkhani M, Patil SB, Huntley GW, Tessier-Lavigne M, Zou H. Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons. Proc Natl Acad Sci U S A. 2011 May 10;108(19):E99-107. PMID: 21518886PDF


    Peer-Reviewed Articles Published by Virovek

    Chen H. Exploiting the intron-splicing mechanism of insect cells to produce viral vectors harboring toxic genes for suicide gene therapy. Mol Ther Nucleic Acids. 2012 Nov 27;1:e57. AAV vectors harboring toxin genes

    Chen H. Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells. Mol Ther. 2008 May;16(5):924-30. Epub 2008 Mar 18. Intron-splicing mediated AAV production


    Selected Peer-Reviewed Articles Citing Virovek’s Published Work

    Gray JT, Zolotukhin S. Design and construction of functional AAV vectors. Methods Mol Biol. 2011;807:25-46. PMID: 22034025 PMID: 22034025PDF

    Galibert L, Merten OW. Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases. J Invertebr Pathol. 2011 Jul;107 Suppl:S80-93. PMID: 21784234

    Lu H, Qu G, Yang X, Xu R, Xiao W. Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver. Hum Gene Ther. 2011 May;22(5):625-32. PMID: 21244243PDF

    Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther. 2009 Nov;17(11):1888-96. PMID: 19532142PDF

    Aslandi G. Lamb K, Zolotukhin S. An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells. Proc Natl Acad Sci USA. 2009 Mar 31;106(13):5059-64. PMID: 19279219PDF

    Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clin Vaccine Immunol. 2009 May;16(5):597-604. PMID: 19244471PDF

    Youjin S, Jun Y. The treatment of hemophilia A: from protein replacement to AAV-mediated gene therapy. Biotechnol Lett. 2009 Mar;31(3):321-8. PMID: 18979215PDF


    Book Chapters Citing Virovek’s Published Work

    Grieger JC, Samulski RJ. Adeno-associated virus vectorology, manufacturing, and clinical applications. Methods Enzymol. 2012;507:229-54. Copyright © 2012 Elsevier Inc. All rights reserved. PMID: 22365777

    Snyder RO, Moullier P. Adeno-Associated Virus: Methods and Protocols (Methods in Molecular Biology) [Hardcover]. Publication Date: October 28, 2011. ISBN-10: 1617793698. ISBN-13: 978-1617796391. Edition: 2011. Springer Protocols publication

    Merten OW, Al-Rubeai M. Viral Vectors for Gene Therapy : Methods and Protocols [Hardcover]. Publication Date: May 19, 2011. ISBN-10: 161779094X. ISBN-13: 978-1617790942. Edition: 2011. Springer Protocols publication